In the 1990s, James Corbett, MD and Edward Ficaro, PhD joined forces at the University of Michigan to develop and automate a quantitative software solution for SPECT cardiac imaging. Over the years, the original application created and implemented at the U-M Medical Center evolved and Drs. Corbett and Ficaro decided to separate from U-M in order to further develop the application. In 2005, INVIA was founded with the objective to further develop 4DM while maintaining the same commitment to quality, accuracy, and excellence. INVIA and the University of Michigan collaborate to support academic and research pursuits.

Dr. James Corbett, Chairman of the Board of INVIA, is currently the Director of Cardiovascular Nuclear Medicine at the University of Michigan as well as a Professor of Internal Medicine and Radiology. He has been published in numerous scientific journals and has 75 peer-reviewed writings to his credit. Dr. Corbett has a B.S. degree in Mechanical Engineering from the University of North Dakota, as well as an M.D. from the University of Minnesota.

Dr. Edward Ficaro earned his BS, MS degrees and Ph.D., in Nuclear Engineering at the University of Michigan and is currently an assistant faculty member and research assistant in the Department of Radiology at U-M. Dr. Edward Ficaro, PhD, President of INVIA, focuses his efforts on ensuring the clinical utility and relevance of 4DM. He is actively involved with the INVIA research team and has collaborated with research institutions and industry partners to co-author publications on the evolution and future of nuclear cardiac imaging.


1990 - Drs. Corbett and Ficaro start development of 4DM at the University of Michigan.

1999 - 4DMSPECT emerges as the standard tool for nuclear cardiology interpretation.

2000 - Siemens, GE, and Philips are participating in commercial sales.

2005 - INVIA separates from the University of Michigan to accelerate product development.


2006 - INVIA adds PET and CT quantification to its flagship product.

2009 - Now multi-lingual, 4DM is available in seven languages.




2010 - INVIA adds Myocardial Flow and Reserve and Planar MUGA quantification.

2012 - Multi-monitor support, automated workflow selector, and support for the Ammonia tracer for Flow and Reserve.

2015 - 4DM is now translated in to 20 languages and has more than 30 reseller partners.

2016 - 4DM Reporting overhauled. Nuclear cardiac specific reporting engine.


2017 - Inflammatory quantification is added for identifying the presence and extent of cardiac sarcoidosis.

Where it All Started